Everything about indazole-3-carboxamide
Substitution at R3 that has a halogen or alkoxy group (74f–74i) brought about a slight rise in cellular potency with the halide analogs (74g–h) demonstrating highest the potency in the group. Further optimization triggered the discovery of 74i–j, with 74k as essentially the most active compound during the collection (pIC50 = 6.seventy seven)